Demethyleneberberine

• CAT Number: R072477
• CAS Number: 25459-91-0
• Molecular Formula: C19H18NO4
• Molecular Weight: 324.35
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(O)C=C4CC3)O

Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.

Reference

[1] Ying-Ying Chen, et al. Inflamm Res. 2017 Feb;66(2):187-196.
[2] Xiaoyan Qiang, et al. Biochem Biophys Res Commun. 2016 Apr 15;472(4):603-9.