DCLX069

• CAT Number: I012686
• CAS Number: 792946-69-1
• Molecular Formula: C20H25N3O2
• Molecular Weight: 339.43
• Purity: ≥95%
• Synonyms: ethyl 3-amino-4-(4-benzylpiperazin-1-yl)benzoate
• InChI: InChI=1S/C20H25N3O2/c1-2-25-20(24)17-8-9-19(18(21)14-17)23-12-10-22(11-13-23)15-16-6-4-3-5-7-16/h3-9,14H,2,10-13,15,21H2,1H3
• InChIKey: RITRCMIWRZBDID-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=CC(=C(C=C1)N2CCN(CC2)CC3=CC=CC=C3)N

DCLX069 (CatNo.: I012686) is an experimental small-molecule inhibitor that targets the stimulator of interferon genes (STING) pathway, a key regulator of innate immune responses. By suppressing aberrant STING activation, DCLX069 helps reduce excessive type I interferon signaling and inflammation. It is being investigated as a potential therapeutic for autoimmune and autoinflammatory disorders, such as systemic lupus erythematosus and Aicardi-Goutières syndrome. As a research tool, DCLX069 provides insights into STING-mediated immunity, highlighting the therapeutic promise of modulating innate immune checkpoints in disease.

Reference

[1]. Yiqian Xie, et al. Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1). Org Biomol Chem. 2014 Dec 21;12(47):9665-73.
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