Amoxicillin is an extended spectrum β-lactam antibiotic and is similar in structure to ampicillin. Resistance to amoxicillin can be attributed to β-lactamase enzymes secreted by a resistant cell.</br>Like all β-lactams, amoxicillin targets PBP’s (penicillin binding proteins) involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised ultimately leading to the death of the cell.
| Catalog Number | A000865 |
| CAS Number | 34642-77-8 |
| Synonyms | Clavulanate |
| Molecular Formula | C16H18N3O5S.Na |
| Purity | 95% |
| Storage | 3 years -20C powder |
| Reference | <p>Guzmán, Flavio, MD. /Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” <em>Medical Pharmacology</em>. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.</p><p>Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.</p></span></p> |
