DCH36_06

• CAT Number: I025611
• CAS Number: 593273-05-3
• Molecular Formula: C18H13ClN2O3S
• Molecular Weight: 372.82
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: 4°C, protect from light
• IUPAC Name: 1-(3-Chloro-4-methylphenyl)-5-(3-(furan-2-yl)allylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• InChI: InChI=1S/C18H13ClN2O3S/c1-11-7-8-12(10-15(11)19)21-17(23)14(16(22)20-18(21)25)6-2-4-13-5-3-9-24-13/h2-10H,1H3,(H,20,22,25)/b4-2+,14-6+
• InChIKey: AYNCXNUUERDREH-FMDPHQNASA-N
• SMILES: O=C(/C(C(N1C2=CC=C(C)C(Cl)=C2)=O)=CC=CC3=CC=CO3)NC1=S

DCH36_06（Cat No.:I025611） is a potent inhibitor of the enzymes p300 and CBP, which play crucial roles in gene regulation. By inhibiting p300/CBP, DCH36_06 demonstrates strong anti-proliferative effects, preventing excessive cell growth. Additionally, it exhibits potent anti-tumor activity in leukemia xenograft models, suggesting its potential as an anticancer therapeutic. The inhibition of p300/CBP by DCH36_06 offers a promising strategy for targeting aberrant gene regulation and suppressing tumor growth in leukemia and potentially other cancer types.

Reference

1: Lu W, Xiong H, Chen Y, Wang C, Zhang H, Xu P, Han J, Xiao S, Ding H, Chen Z, Lu T, Wang J, Zhang Y, Yue L, Liu YC, Zhang C, Yang Y, Jiang H, Chen K, Zhou B, Luo C. Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors. Bioorg Med Chem. 2018 Nov 1;26(20):5397-5407. doi: 10.1016/j.bmc.2018.07.048. Epub 2018 Jul 27. PubMed PMID: 30297119.