DC07090 dihydrochloride

• CAT Number: I025591
• CAS Number: 1158264-37-9
• Molecular Formula: C18H16Cl2N4O
• Molecular Weight: 375.25
• Purity: ≥95%
• Synonyms: 4-([1,3]oxazolo[4,5-b]pyridin-2-yl)-N-(pyridin-2-ylmethyl)aniline;dihydrochloride
• InChI: InChI=1S/C18H14N4O.2ClH/c1-2-10-19-15(4-1)12-21-14-8-6-13(7-9-14)18-22-17-16(23-18)5-3-11-20-17;;/h1-11,21H,12H2;2*1H
• InChIKey: NLHMKUDAEGGODS-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)CNC2=CC=C(C=C2)C3=NC4=C(O3)C=CC=N4.Cl.Cl

DC07090 dihydrochloride (Cat No.: I025591) is a small-molecule inhibitor targeting the sodium–calcium exchanger (NCX), a critical membrane transporter involved in regulating intracellular calcium homeostasis in excitable cells such as cardiomyocytes and neurons. By blocking NCX activity, DC07090 alters calcium influx and efflux, affecting excitation–contraction coupling in the heart and calcium-dependent signaling in the nervous system. The dihydrochloride salt form improves solubility and stability. It is used in cardiovascular and neuroscience research to study calcium dynamics, ischemia–reperfusion injury, arrhythmias, and calcium-mediated neuronal processes.

Reference

[1]. Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991.
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