DC0-NH2

• CAT Number: I017797
• CAS Number: 615538-51-7
• Molecular Formula: C₃₁H₂₄ClN₅O₃
• Molecular Weight: 550.01
• Purity: ≥95%
• IUPAC Name: 5-amino-N-[2-[(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indole-3-carbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide
• InChI: InChI=1S/C31H24ClN5O3/c32-14-18-15-37(27-13-28(38)21-3-1-2-4-22(21)29(18)27)31(40)26-12-17-10-20(6-8-24(17)36-26)34-30(39)25-11-16-9-19(33)5-7-23(16)35-25/h1-13,18,35-36,38H,14-15,33H2,(H,34,39)/t18-/m1/s1
• InChIKey: PANFWPQOVGEWSD-GOSISDBHSA-N
• SMILES: C1C(C2=C(N1C(=O)C3=CC4=C(N3)C=CC(=C4)NC(=O)C5=CC6=C(N5)C=CC(=C6)N)C=C(C7=CC=CC=C72)O)CCl

DC0-NH2 (Cat No.: I017797) is the effector part of ADC, an analog of DC1 with higher stability. The cytotoxicity of DC0-NH2 is about 1000 times higher than that of commonly used anti-cancer drugs (eg, doxorubicin). DCO-NH2 can bind to smaller DNA grooves and subsequently alkylate adenine residues via its prop indole (CBI) moiety.

Reference

[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55(2):766-82.