DC 260126

• CAT Number: I011174
• CAS Number: 346692-04-4
• Molecular Formula: C16H18FNO2S
• Molecular Weight: 307.38
• Purity: ≥95%
• Target: FFAR1 (GPR40)
• Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
• Storage: -20°C
• IUPAC Name: N-(4-butylphenyl)-4-fluorobenzenesulfonamide
• InChI: InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3
• InChIKey: CNGHPXKWPGIDSK-UHFFFAOYSA-N
• SMILES: CCCCC1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)F

DC260126（Cat No.:I011174） is a potent antagonist of the GPR40 receptor, also known as FFAR1. It effectively inhibits the increase in intracellular calcium levels mediated by GPR40 activation in response to various fatty acids, such as linoleic acid, oleic acid, palmitoleic acid, and lauric acid. With IC50 values ranging from 4.58 to 7.07 μM, DC260126 demonstrates dose-dependent inhibition. Additionally, DC260126 has shown protective effects against endoplasmic reticulum stress and apoptosis induced by palmitate.