For research use only. Not for therapeutic Use.
DBPR112(Cat No.:I017821)is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor developed for the treatment of type 2 diabetes mellitus. By blocking DPP-4 activity, it prolongs the half-life of incretin hormones such as GLP-1 and GIP, enhancing insulin secretion while reducing glucagon release in a glucose-dependent manner. This leads to improved glycemic control without significant risk of hypoglycemia. DBPR112 has demonstrated favorable pharmacokinetics, safety, and efficacy in preclinical and clinical studies. It represents a promising therapeutic candidate for managing diabetes and related metabolic disorders.
CAS Number | 1226549-49-0 |
Synonyms | (E)-4-(dimethylamino)-N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]but-2-enamide |
Molecular Formula | C32H31N5O3 |
Purity | ≥95% |
IUPAC Name | (E)-4-(dimethylamino)-N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]but-2-enamide |
InChI | InChI=1S/C32H31N5O3/c1-37(2)18-10-17-27(39)35-25-16-9-15-24(19-25)28-29-31(36-26(20-38)22-11-5-3-6-12-22)33-21-34-32(29)40-30(28)23-13-7-4-8-14-23/h3-17,19,21,26,38H,18,20H2,1-2H3,(H,35,39)(H,33,34,36)/b17-10+/t26-/m1/s1 |
InChIKey | NQAMTZUVRFRJCZ-VMMYIZNOSA-N |
SMILES | CN(C)C/C=C/C(=O)NC1=CC=CC(=C1)C2=C(OC3=NC=NC(=C23)N[C@H](CO)C4=CC=CC=C4)C5=CC=CC=C5 |
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