DBCO-PEG3-oxyamine

• CAT Number: I045955
• CAS Number: 2748394-67-2
• Molecular Formula: C29H36N4O7
• Molecular Weight: 552.62
• Purity: ≥95%
• Synonyms: N-[2-[2-[2-[2-[(2-aminooxyacetyl)amino]ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide
• InChI: InChI=1S/C29H36N4O7/c30-40-22-28(35)32-14-16-38-18-20-39-19-17-37-15-13-31-27(34)11-12-29(36)33-21-25-7-2-1-5-23(25)9-10-24-6-3-4-8-26(24)33/h1-8H,11-22,30H2,(H,31,34)(H,32,35)
• InChIKey: JRBITMATWRXIQO-UHFFFAOYSA-N
• SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCOCCNC(=O)CON

DBCO-PEG3-oxyamine(CAT: I045955) is a heterobifunctional PEG-based linker containing a dibenzocyclooctyne (DBCO) group and an oxyamine functionality, separated by a triethylene glycol (PEG3) spacer. The DBCO moiety enables rapid, copper-free strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-containing biomolecules, providing highly selective and biocompatible click chemistry. The oxyamine group reacts efficiently with aldehydes and ketones to form stable oxime linkages, expanding conjugation versatility. The PEG3 spacer enhances solubility, flexibility, and reduces steric hindrance, ensuring efficient coupling in biological systems. DBCO-PEG3-oxyamine is widely applied in inhibitor development, antibody–drug conjugates, and probe design for cancer, immunology, and metabolic disease research requiring dual chemoselective reactivity.