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DBCO-NHS Ester

DBCO-NHS Ester

  • CAT Number: R030920
  • CAS Number: 1353016-71-3
  • Molecular Formula: C23H18N2O5
  • Molecular Weight: 402.406
  • Purity: ≥95%
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DBCO-NHS ester (Cat. No: R030920) is a cleavable ADC linker for the synthesis of antibody-conjugated drugs (ADCs). It can also be used in click chemical reactions, such as strain-promoted copper-free azide-alkyne cycloaddition reactions.

Catalog Number R030920
CAS Number 1353016-71-3
Molecular Formula

C23H18N2O5

Purity 95%
Storage -20°C
IUPAC Name (2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoate
InChI InChI=1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2
InChIKey XCEBOJWFQSQZKR-UHFFFAOYSA-N
SMILES C1CC(=O)N(C1=O)OC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
Reference

<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>1.Yan, Junhong, et al. &quot;A universal approach to prepare reagents for DNA-assisted protein analysis.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>PloS one</i>&nbsp;9.9 (2014): e108061.<br />
2.Murrey, Heather E., et al. &quot;Systematic evaluation of bioorthogonal reactions in live cells with clickable HaloTag ligands: implications for intracellular imaging.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Journal of the American Chemical Society</i>&nbsp;137.35 (2015): 11461-11475.</span></span></span>

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