DB07268

• CAT Number: I005524
• CAS Number: 929007-72-7
• Molecular Formula: C₁₇H₁₅N₅O₂
• Molecular Weight: 321.34
• Purity: ≥95%
• Target: JNK
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: Store at -20°C
• IC50: 9 nM (Human JNK1)
• InChI: 1S/C17H15N5O2/c18-16(24)13-6-1-2-7-14(13)21-15-8-9-19-17(22-15)20-11-4-3-5-12(23)10-11/h1-10,23H,(H2,18,24)(H2,19,20,21,22)
• InChIKey: QHPKKGUGRGRSGA-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)N)NC2=NC(=NC=C2)NC3=CC(=CC=C3)O

DB07268(CAT: I005524) emerges as a notable compound in the landscape of pharmaceutical and medicinal chemistry. This potent and selective inhibitor of c-Jun N-terminal kinase 1 (JNK1) showcases an impressive IC50 value of 9 nM. Its precise targeting of JNK1, a kinase involved in various cellular processes, suggests potential applications in therapeutic interventions related to inflammation, apoptosis, and stress response pathways. While demonstrating selectivity over several kinases, including CHK1, CK2, and PLK, DB07268’s exceptional potency against JNK1 underscores its importance as a tool compound for unraveling JNK1-associated signaling pathways and validating its role in disease pathways.

Reference

[1]. Liu M, et al. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. 


[2]. Madhavan T, et al. 3D-QSAR studies of JNK1 inhibitors utilizing various alignment methods. Chem Biol Drug Des. 2012 Jan;79(1):53-67.
[3]. Xinyi Song, et al. Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors. MedChemComm (2012), 3(2), 238-243.