Darifenacin

• CAT Number: I001262
• CAS Number: 133099-04-4
• Molecular Formula: C28H30N2O2
• Molecular Weight: 426.55
• Purity: ≥95%
• Target: Muscarinic Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 8.9 (pKi) [1]
• IUPAC Name: 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
• InChI: InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1
• InChIKey: HXGBXQDTNZMWGS-RUZDIDTESA-N
• SMILES: C1CN(C[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5

Darifenacin (Cat.No:I001262) is a medication used in the treatment of overactive bladder (OAB) symptoms, including frequent urination and urge incontinence. It belongs to the class of antimuscarinic agents, which work by relaxing the bladder muscles and reducing urinary urgency. 

Reference

[1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.

[2]. Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638.

[3]. Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847.