Danshensu

• CAT Number: I004833
• CAS Number: 76822-21-4
• Molecular Formula: C9H10O5
• Molecular Weight: 198.17
• Purity: ≥95%
• Solubility: H2O: ≥ 6.2 mg/mL (Need ultrasonic or warming)
• Storage: Store at -20C

Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit.IC50 value:Target:In vitro: Danshensu (DSS) significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R injury. DSS also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis[2].In vivo: Acute treatment with a single dose of danshensu in rats with normal tHcy did not change plasma tHcy. In contrast, danshensu significantly lowered tHcy in rats with elevated tHcy. The relatively higher cysteine and glutathione levels after treatment with danshensu indicated that its tHcy-lowering effect was via increased activity of the trans-sulphuration pathway[1].

Reference

[1]. YG Cao, et al. Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats. Br J Pharmacol. 2009 Jun; 157(3): 482–490.
[2]. Yu J, et al. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling. Int J Clin Exp Med. 2015 Sep 15;8(9):14793-804.
[3]. Chen J, et al. Study on regulatory effect of Danshensu on lipid metabolism of hyperlipidemia rats. Zhongguo Zhong Yao Za Zhi. 2015 Jan;40(2):313-7.