D-myo-Inositol-2,4,5-triphosphate (sodium salt)

• CAT Number: R018455
• Molecular Formula: C6H12O15P3 · 3Na
• Molecular Weight: 486
• Purity: ≥95%
• Synonyms: Ins(2,4,5)P3 (sodium salt);2,4,5-IP3 (sodium salt)
• Storage: -20°C
• InChI: InChI=1S/C6H15O15P3.3Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2-,3-,4?,5?,6?;;;/m0.../s1
• InChIKey: ZVCVTWVBDIPWPZ-UIEDNGEDSA-K
• SMILES: O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]

The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, D-<wbr></wbr>myo-<wbr></wbr>Inositol-<wbr></wbr>2,4,5-<wbr></wbr>triphosphate (sodium salt) (Ins(1,4,5)P3), more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-<wbr></wbr>mediated hydrolysis of phosphatidylinositol-<wbr></wbr>4,5-<wbr></wbr>biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(2,4,5)P3 is a metabolically stable analog of Ins(1,4,5)P3 that is commonly used to study Ca

Reference

1.Majerus, P.W. Inositol phosphate biochemistry. Annual Reviews of Biochemistry 61, 225-250 (1992).