D-Fructose-6-phosphate (sodium salt)

• CAT Number: R066589
• CAS Number: 26177-86-6
• Molecular Formula: C6H11O9P • 2Na
• Molecular Weight: 304.1
• Purity: ≥95%
• Storage: -20°C
• InChI: InChI=1S/C6H11O9P.2Na/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h4-6,9,11H,1-2H2,(H2,12,13,14);;/q-2;2*+1/t4-,5-,6-;;/m1../s1
• InChIKey: UNCUTLNWSBJTSG-CCXTYWFUSA-N
• SMILES: [O-]CC([C@H]([C@@H]([C@@H](COP(O)(O)=O)O)O)[O-])=O.[Na+].[Na+]

D-Fructose-6-phosphate is a sugar intermediate of the glycolytic pathway formed by the isomerization of glucose-6-phosphate. It is in turn further phosphorylated to fructose-1,6-bisphosphate, which is one of the rate-limiting steps in glycolysis. Because cancer cells adopt glycolysis as a major source of metabolic energy production, this pathway has become a new target for cancer chemotherapy. D-Fructose-6-phophate can be used to help identify, differentiate, and characterize the enzymes in this process.

Reference

1.Seo, M.,Kim, J.D.,Neau, D., et al. Structure-based development of small molecule PFKFB3 inhibitors: A framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6(9), 1-12 (2011).