CYM-5478

• CAT Number: I025417
• CAS Number: 870762-83-7
• Molecular Formula: C21H19F3N2O2
• Molecular Weight: 388.38
• Purity: ≥95%
• Synonyms: 1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]-5-(trifluoromethyl)pyridin-2-one
• InChI: InChI=1S/C21H19F3N2O2/c1-14-10-18(15(2)26(14)11-16-6-4-3-5-7-16)19(27)13-25-12-17(21(22,23)24)8-9-20(25)28/h3-10,12H,11,13H2,1-2H3
• InChIKey: RGSGTUIDJXHTTO-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(N1CC2=CC=CC=C2)C)C(=O)CN3C=C(C=CC3=O)C(F)(F)F

CYM-5478 (Cat No.: I025417) is a selective small-molecule agonist of the sphingosine-1-phosphate receptor 2 (S1P2). By activating this receptor, it influences key cellular processes such as migration, vascular regulation, and immune responses. Researchers use CYM-5478 to probe the physiological and pathological roles of S1P2 signaling, particularly in cardiovascular biology, inflammation, and cancer research. Its selectivity makes it a valuable tool for distinguishing S1P2-mediated effects from other S1P receptor subtypes. While not developed for therapeutic use, CYM-5478 advances understanding of sphingolipid receptor biology.

Reference

[1]. Deron R Herr, et al. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Sci Rep. 2016 Apr 15;6:24541.
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[2]. Wei Wang, et al. Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment. Cancers (Basel). 2020 Jan 15;12(1):211.
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