Cycrimine

• CAT Number: I005950
• CAS Number: 77-39-4
• Molecular Formula: C19H29NO
• Molecular Weight: 287.45
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: 1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
• InChI: InChI=1S/C19H29NO/c21-19(18-11-5-6-12-18,17-9-3-1-4-10-17)13-16-20-14-7-2-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
• InChIKey: SWRUZBWLEWHWRI-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCC(C2CCCC2)(C3=CC=CC=C3)O

Cycrimine (Cat.No:I005950) is a central anticholinergic drug designed to reduce the levels of acetylcholine in the treatment of Parkinson/’s disease. Its mechanism of action is to bind to the muscarinic acetylcholine receptor M1.

Reference

1:Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. Owen JA, Sribney M, Lawson JS, Delva N, Letemendia FJ.J Chromatogr. 1989 Sep 29;494:135-42. PMID: 2573609 2:Cycrimine on rat diaphragm. Vedasiromoni JR, Ganguly DK.Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. PMID: 1267542 3:Effectiveness of procyclidine hydrochloride (kemadrin) and cycrimine hydrochloride (pagitane) in the prevention of airsickness. RENZI AA, MILCH LJ.J Aviat Med. 1958 Aug;29(8):587-9. No abstract available. PMID: 13575361 4:[Cycrimine, a new drug in the treatment of Parkinson/’s disease & Parkinsonism]. KAFER JP, POCH GF.Prensa Med Argent. 1957 Apr 5;44(14):1071-5. Spanish. No abstract available. PMID: 13477721 5:[Symptomatic therapeutic effect of cycrimine HCl in parkinsonian syndromes]. SIGWALD J, PAYOT J.Presse Med. 1955 Mar 12;63(19):375-6. French. No abstract available. PMID: 14371520 6:NEW AND nonofficial remedies: cycrimine hydrochloride. [No authors listed]J Am Med Assoc. 1955 Feb 5;157(6):510-1. No abstract available. PMID: 13221464