Cyclopenthiazide

• CAT Number: R057173
• CAS Number: 742-20-1
• Molecular Formula: C13H18ClN3O4S2
• Molecular Weight: 379.874
• Purity: ≥95%
• Synonyms: 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; Benesal; Ciba 8341-Su; Cyclomethiazide; Cyclometiazid; Cyclopentiazid; NSC 107679; Navidreks; Navidrex; Navidrix; Salimed; Salimid; Salurilo-C; Su 8341; 6
• Storage: Store at +4C
• IUPAC Name: 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6}
• InChI: InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)
• InChIKey: BKYKPTRYDKTTJY-UHFFFAOYSA-N
• SMILES: C1CCC(C1)CC2NC3=CC(=C(C=C3S(=O)(=O)N2)S(=O)(=O)N)Cl

Cyclopenthiazide is a thiazide diuretic used in the treatment of heart failure and hypertension. It increases the excretion of sodium and potassium ions and decrease the excretion of calcium ions and uric acid so they are contraindicated in patients with hyponatraemia, hypokalaemia, hypercalcaemia and hyperuricaemia.

Reference

1:Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide. Krum H, Jackson B, Conway EL, Howes LG, Johnston CI, Louis WJ.J Cardiovasc Pharmacol. 1992 Sep;20(3):451-7. PMID: 1279292 2:The antihypertensive and metabolic effects of low and conventional dose cyclopenthiazide in type II diabetics with hypertension. Passmore AP, Whitehead EM, Crawford V, McVeigh GE, Johnston GD.Q J Med. 1991 Nov;81(295):919-28. PMID: 1808632 3:Low-dose cyclopenthiazide in the treatment of hypertension: a one-year community-based study. Johnston GD, Wilson R, McDermott BJ, McVeigh GE, Duffin D, Logan J.Q J Med. 1991 Feb;78(286):135-43. PMID: 2031076 4:An open, parallel group study comparing a frusemide/amiloride diuretic and a diuretic containing cyclopenthiazide with sustained release potassium in the treatment of congestive cardiac failure–a multicentre general practice study. Allman S, Norris RJ.J Int Med Res. 1990;18 Suppl 2:17B-23B. PMID: 2193840 5:A comparison of the haemodynamic and hormonal effects of low and conventional dose cyclopenthiazide in normal volunteers. McVeigh GE, McMaster M, Linton T, Whitehead E, Johnston GD.Eur J Clin Pharmacol. 1990;38(4):351-7. PMID: 2188845 6:Low and conventional dose cyclopenthiazide on glucose and lipid metabolism in mild hypertension. McVeigh GE, Dulie EB, Ravenscroft A, Galloway DB, Johnston GD.Br J Clin Pharmacol. 1989 Apr;27(4):523-6. PMID: 2655692 Free PMC Article7:Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide. Harding JJ, van Heyningen R.Br J Ophthalmol. 1988 Nov;72(11):809-14. PMID: 3207655 Free PMC Article8:The case for low dose diuretics in hypertension: comparison of low and conventional doses of cyclopenthiazide. McVeigh G, Galloway D, Johnston D.BMJ. 1988 Jul 9;297(6641):95-8. PMID: 3044503 Free PMC Article9:Effect of low versus conventional dose cyclopenthiazide on platelet intracellular calcium in mild essential hypertension. McVeigh GE, Copeland S, McKellar J, Johnston D.J Hypertens. 1988 Apr;6(4):337-41. PMID: 3288695 10:A comparative study of frusemide-amiloride and cyclopenthiazide-potassium chloride in the treatment of congestive cardiac failure in general practice. Crawford RJ, Allman S, Gibson W, Kitchen S, Richards HH.J Int Med Res. 1988 Mar-Apr;16(2):143-9. PMID: 3378660