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Cycloguanil Hydrochloride

Cycloguanil Hydrochloride

  • CAT Number: R008546
  • CAS Number: 152-53-4
  • Molecular Formula: C11H15Cl2N5
  • Molecular Weight: 288.176
  • Purity: ≥95%
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Cycloguanil Hydrochloride (CAT: R008546) is a pharmacologically significant compound primarily utilized in antimalarial research. It targets the enzyme dihydrofolate reductase (DHFR) in Plasmodium falciparum, disrupting the synthesis of essential tetrahydrofolate cofactors required for nucleotide production. This inhibition hinders the parasite’s DNA and RNA replication, leading to growth arrest. Cycloguanil Hydrochloride demonstrates potent antimalarial properties, especially against drug-resistant Plasmodium falciparum strains. It has been employed in combination therapies for treating malaria, contributing to multidrug regimens to enhance efficacy and counter resistance.

Catalog Number R008546
CAS Number 152-53-4
Molecular Formula

C11H15Cl2N5

Purity 95%
Target DHFR
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine;hydrochloride
InChI InChI=1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H
InChIKey MOUAPRKJJUXEIE-UHFFFAOYSA-N
SMILES CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.Cl

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