Cyclo(his-pro)

• CAT Number: I006336
• CAS Number: 53109-32-3
• Molecular Formula: C11H14N4O2
• Molecular Weight: 234.259
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• SMILES: O=C(N[C@H]1CC2=CNC=N2)[C@@](CCC3)([H])N3C1=O

Cyclo(his-pro) is a cyclic dipeptide derived from the hydrolytic removal of the amino-terminal pyroglutamic acid residue of the hypothalamic thyrotropin-releasing hormone, may be important in regulating the nature of the glial cell contribution. Cyclo(His-Pro) is ubiquitous in the central nervous system and is a key substrate of organic cation transporters, which are strongly linked to neuroprotection. Cyclo(His-Pro) has striking potential for therapeutic application by both parenteral and oral administration routes and may represent an important new tool in counteracting neuroinflammation-based degenerative pathologies.

Reference

1:Kastin AJ, Pan W. Involvement of the Blood-Brain Barrier in Metabolic Regulation. CNS Neurol Disord Drug Targets. 2016 Sep 20. [Epub ahead of print] PubMed PMID: 27658512. 2:Grottelli S, Ferrari I, Pietrini G, Peirce MJ, Minelli A, Bellezza I. The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17(8). pii: E1332. doi: 10.3390/ijms17081332. Review. PubMed PMID: 27529240; PubMed Central PMCID: PMC5000729.