CX546

• CAT Number: I002654
• CAS Number: 215923-54-9
• Molecular Formula: C14H17NO3
• Molecular Weight: 247.29
• Purity: ≥95%
• Target: AMPAR
• Solubility: 100 mM in DMSO； 100 mM in ethanol；
• Storage: 2-8°C
• IUPAC Name: 2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone
• InChI: InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
• InChIKey: LJUNPHMOGNFFOS-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)C(=O)C2=CC3=C(C=C2)OCCO3

CX546（Cat No.:I002654） is a representative ampakine compound known for its selective positive modulation of AMPA receptors. As a positive modulator, it enhances the activity of AMPA receptors, which are important for synaptic transmission and plasticity in the brain. By increasing the activity of these receptors, CX546 can enhance excitatory neurotransmission and potentially improve cognitive functions.

Reference

1:Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures. Schitine C, Xapelli S, Agasse F, Sardà-Arroyo L, Silva AP, De Melo Reis RA, de Mello FG, Malva JO.Eur J Neurosci. 2012 Jun;35(11):1672-83. doi: 10.1111/j.1460-9568.2012.08072.x. Epub 2012 Apr 16. PMID: 22506985 2:Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4/transmembrane AMPA receptor regulatory protein combinations. Montgomery KE, Kessler M, Arai AC.J Pharmacol Exp Ther. 2009 Dec;331(3):965-74. doi: 10.1124/jpet.109.158014. Epub 2009 Aug 28. PMID: 19717789 Free PMC Article3:The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Lipina T, Weiss K, Roder J.Neuropsychopharmacology. 2007 Apr;32(4):745-56. Epub 2006 Aug 23. PMID: 16936708 Free Article4:Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators. Pellerin L, Magistretti PJ.J Neurochem. 2005 Feb;92(3):668-77. PMID: 15659236 Free Article5:Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Nagarajan N, Quast C, Boxall AR, Shahid M, Rosenmund C.Neuropharmacology. 2001 Nov;41(6):650-63. PMID: 11640919