For research use only. Not for therapeutic Use.
CWP232228(CAT: I017465) is a highly potent and selective Wnt/β-catenin signaling inhibitor that blocks the interaction of β-catenin with T-cell factor (TCF) in the nucleus. It effectively targets and suppresses the growth of cancer stem cells (CSCs), reducing tumor formation and metastasis without significant toxicity. CWP232228 inhibits proliferation in breast cancer cells with IC50 values of 2 μM (4T1, mouse) and 0.8 μM (MDA-MB-435, human), as well as in hepatocellular carcinoma cells (Hep3B, Huh7, HepG2; IC50 ~2.6 μM). In vivo, daily intraperitoneal dosing (100 mg/kg) significantly reduces tumor burden in breast and liver cancer models.
| CAS Number | 1144044-02-9 |
| Synonyms | disodium;[4-[[(6S,9aS)-1-(benzylcarbamoyl)-8-[(2-methylindazol-7-yl)methyl]-4,7-dioxo-2-prop-2-enyl-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazin-6-yl]methyl]phenyl] phosphate |
| Molecular Formula | C33H34N7Na2O7P |
| Purity | ≥95% |
| IUPAC Name | disodium;[4-[[(6S,9aS)-1-(benzylcarbamoyl)-8-[(2-methylindazol-7-yl)methyl]-4,7-dioxo-2-prop-2-enyl-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazin-6-yl]methyl]phenyl] phosphate |
| InChI | InChI=1S/C33H36N7O7P.2Na/c1-3-16-38-22-30(41)39-28(17-23-12-14-27(15-13-23)47-48(44,45)46)32(42)37(20-26-11-7-10-25-19-36(2)35-31(25)26)21-29(39)40(38)33(43)34-18-24-8-5-4-6-9-24;;/h3-15,19,28-29H,1,16-18,20-22H2,2H3,(H,34,43)(H2,44,45,46);;/q;2*+1/p-2/t28-,29-;;/m0../s1 |
| InChIKey | KKMKZLQVDAGSOA-GDUXWEAWSA-L |
| SMILES | CN1C=C2C=CC=C(C2=N1)CN3CC4N(C(C3=O)CC5=CC=C(C=C5)OP(=O)([O-])[O-])C(=O)CN(N4C(=O)NCC6=CC=CC=C6)CC=C.[Na+].[Na+] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
