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Bromo-PEG2-C2-acid

Bromo-PEG2-C2-acid

  • CAT Number: I016473
  • CAS Number: 1807503-92-9
  • Molecular Formula: C₇H₁₃BrO₄
  • Molecular Weight: 241.08
  • Purity: ≥95%
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Bromo-PEG2-C2-acid(CAT: I016473) is a PEG-based PROTAC linker. This linker molecule is specifically designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras), a class of compounds that induce targeted protein degradation by harnessing the cellular ubiquitin-proteasome system. The presence of a bromo group, a PEG chain, and a C2-acid moiety in this compound allows it to facilitate the connection between the target protein-binding ligand and the E3 ligase-binding ligand in a PROTAC molecule.

Catalog Number I016473
CAS Number 1807503-92-9
Molecular Formula

C₇H₁₃BrO₄

Purity 95%
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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