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Curcumin, Curcuma longa (High Purity)

Curcumin, Curcuma longa (High Purity)

  • CAT Number: A001131
  • CAS Number: 458-37-7
  • Molecular Formula: C₂₁H₂₀O₆
  • Molecular Weight: 368.38
  • Purity: ≥95%
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Curcumin is a diarylheptanoid. It is the principal curcuminoid of turmeric, which is a member of the ginger family (Zingiberaceae). Turmeric/’s other two curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin. Curcumin is a bright-yellow color and may be used as a food coloring. As a food additive, its E number is E100. A survey of the literature shows a number of potential effects under study and that daily doses over a 3-month period of up to 12 grams were safe. Clinical trials in humans are studying the effect of curcumin on various diseases, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis, arthritis, major depressive disorder and Alzheimer/’s disease.

Catalog Number A001131
CAS Number 458-37-7
Molecular Formula

C₂₁H₂₀O₆

Purity 95%
Target KEAP1-Nrf2
Solubility Soluble in DMSO > 10 mM
Storage 3 years -20C powder
InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChIKey VFLDPWHFBUODDF-FCXRPNKRSA-N
SMILES COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
Reference

</br>1:Curcumin May (Not) Defy Science. Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA.ACS Med Chem Lett. 2017 May 11;8(5):467-470. doi: 10.1021/acsmedchemlett.7b00139. eCollection 2017 May 11. No abstract available. PMID: 28523093 </br>2:Structure and Activity Relationship of Curcumin: Role of Methoxy Group in Anti-inflammatory and Anti-colitis Effects of Curcumin. Yang H, Du Z, Wang W, Song M, Sanidad KZ, Sukamtoh E, Zheng J, Tian L, Xiao H, Liu Z, Zhang G.J Agric Food Chem. 2017 May 17. doi: 10.1021/acs.jafc.7b01792. [Epub ahead of print] PMID: 28513174 </br>3:Uptake of Ga-curcumin derivatives in different cancer cell lines: Toward the development of new potential <sup>68</sup>Ga-labelled curcuminoids-based radiotracers for tumour imaging. Rubagotti S, Croci S, Ferrari E, Orteca G, Iori M, Capponi PC, Versari A, Asti M.J Inorg Biochem. 2017 May 10;173:113-119. doi: 10.1016/j.jinorgbio.2017.05.002. [Epub ahead of print] PMID: 28511061 </br>4:Anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in ovalbumin-sensitized rat. Shakeri F, Boskabady MH.Biofactors. 2017 May 16. doi: 10.1002/biof.1364. [Epub ahead of print] PMID: 28509396 </br>5:A review of curcumin as a biological stain and as a self-visualizing pharmaceutical agent. Hope-Roberts M, Horobin RW.Biotech Histochem. 2017 May 16:1-9. doi: 10.1080/10520295.2017.1310925. [Epub ahead of print] PMID: 28506128 </br>6:NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet. Amato A, Caldara GF, Nuzzo D, Baldassano S, Picone P, Rizzo M, Mulè F, Di Carlo M.Nutrients. 2017 May 13;9(5). pii: E492. doi: 10.3390/nu9050492. PMID: 28505074 Free Article</br>7:d-α-Tocopheryl Succinate/Phosphatidyl Ethanolamine Conjugated Amphiphilic Polymer-Based Nanomicellar System for the Efficient Delivery of Curcumin and To Overcome Multiple Drug Resistance in Cancer. Muddineti OS, Kumari P, Ghosh B, Torchilin VP, Biswas S.ACS Appl Mater Interfaces. 2017 May 15. doi: 10.1021/acsami.7b01087. [Epub ahead of print] PMID: 28504884 </br>8:Curcumin enhances vascular contractility via induction of myocardin in mouse smooth muscle cells. Sun SW, Tong WJ, Guo ZF, Tuo QH, Lei XY, Zhang CP, Liao DF, Chen JX.Acta Pharmacol Sin. 2017 May 1. doi: 10.1038/aps.2017.18. [Epub ahead of print] PMID: 28504250 </br>9:Propoxur-induced oxidative DNA damage in human peripheral blood mononuclear cells: protective effects of curcumin and α-tocopherol. Ahmed T, Goel V, Banerjee BD.Drug Chem Toxicol. 2017 May 15:1-7. doi: 10.1080/01480545.2017.1321010. [Epub ahead of print] PMID: 28504020 </br>10:Curcumin-loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich/’s ascites carcinoma bearing mice. Kumari M, Ray L, Purohit MP, Patnaik S, Pant AB, Shukla Y, Kumar P, Gupta KC.Eur J Pharm Biopharm. 2017 May 9. pii: S0939-6411(16)30437-4. doi: 10.1016/j.ejpb.2017.05.003. [Epub ahead of print] PMID: 28499854

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