Cucurbitacin B

• CAT Number: I004339
• CAS Number: 6199-67-3
• Molecular Formula: C32H46O8
• Molecular Weight: 558.7
• Purity: ≥95%
• Target: anticancer natural compound
• Solubility: 10 mM in DMSO
• Storage: Keep in dark place,Sealed in dry,2-8°C
• IUPAC Name: [(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
• InChI: InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1
• InChIKey: IXQKXEUSCPEQRD-DKRGWESNSA-N
• SMILES: CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)C)C)C)O)O

Cucurbitacin B（Cat No.:I004339） is a tetracyclic triterpenoid compound derived from the fruit stem of the Cucurbitaceae Melon. It possesses various therapeutic properties, including heat-clearing, detoxifying, and inhibiting liver fibrosis. Cucurbitacin B exhibits effects in reversing cellular immune deficiency, stimulating cellular immune function, preventing hepatic fatty degeneration, and inhibiting liver fibrosis. It can help alleviate symptoms such as jaundice, reduce serum alanine aminotransferase levels, and improve protein metabolism. Clinically, it is used for the treatment of chronic persistent hepatitis and shows promise as a therapeutic option for liver-related disorders.

Reference

[1]. Shang Y, et al. Cucurbitacin-B inhibits neuroblastoma cell proliferation through up-regulation of PTEN. Eur Rev Med Pharmacol Sci. 2014;18(21):3297-303.

[2]. Zhang M, et al. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Mol Med Rep. 2014 Dec;10(6):2905-11.

[3]. Gupta P, et al. Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. Oncotarget. 2014 Apr 15;5(7):1812-28.

[4]. Guo J, et al. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. PLoS One. 2014 Feb 4;9(2):e88140.