For research use only. Not for therapeutic Use.
CU-115 (Cat No.: I045434) is a selective inhibitor of histone acetyltransferase (HAT) p300/CBP, enzymes that regulate gene transcription by acetylating histones and non-histone proteins. By blocking p300/CBP activity, CU-115 reduces histone acetylation, leading to altered chromatin structure and transcriptional repression of specific genes. It is used in epigenetics research to study transcriptional regulation, cancer biology, and inflammation. CU-115 has potential therapeutic relevance in oncology, where p300/CBP overactivity contributes to tumor progression, making it a valuable tool for drug discovery and mechanistic studies.
| CAS Number | 2471982-20-2 |
| Synonyms | N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodobenzamide |
| Molecular Formula | C21H11F7INO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H11F7INO2/c22-16-2-1-3-17(29)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(23,24)25)8-12(10-15)21(26,27)28/h1-10H,(H,30,31) |
| InChIKey | QYSLCRYVUJORPX-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)I)C(=O)NC2=CC=C(C=C2)OC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)F |
| Reference | [1]. Rosaura Padilla-Salinas, et al. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62(22):10221-10244. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
