CTX1

• CAT Number: I012913
• CAS Number: 501935-96-2
• Molecular Formula: C₁₄H₁₀N₄
• Molecular Weight: 234.26
• Purity: ≥95%
• Target: MDM-2/p53
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: 3,6-diaminoacridine-9-carbonitrile
• InChI: InChI=1S/C14H10N4/c15-7-12-10-3-1-8(16)5-13(10)18-14-6-9(17)2-4-11(12)14/h1-6H,16-17H2
• InChIKey: PUMGFEMNXBLDKD-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1N)N=C3C=C(C=CC3=C2C#N)N

CTX1（Cat No.:I012913） is a compound known as a p53 activator, capable of counteracting the inhibitory effects of HdmX on p53 function. By activating p53, CTX1 has demonstrated strong anticancer activity in a mouse model of acute myeloid leukemia (AML). AML is a type of blood cancer characterized by the rapid growth of abnormal myeloid cells. The ability of CTX1 to overcome HdmX-mediated p53 repression suggests its potential as a therapeutic agent for treating AML and potentially other cancers where p53 regulation is disrupted.

Reference

[1]. Karan G, et al. Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. Mol Cancer Ther. 2016 Apr;15(4):574-582.