CTOP TFA

• CAT Number: I045801
• Molecular Formula: C50H67N11O11S2
• Molecular Weight: 1062.27 (free base)
• Purity: ≥95%
• IUPAC Name: N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-19-[(2-amino-3-phenylpropanoyl)amino]-10-(3-aminopropyl)-7-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
• InChI: InChI=1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
• InChIKey: PZWWYAHWHHNCHO-UHFFFAOYSA-N
• SMILES: CC(C1C(=O)NC(C(SSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)(C)C)C(=O)NC(C(C)O)C(=O)N)O

CTOP TFA（Cat No.:I045801）is the trifluoroacetate salt form of the synthetic peptide CTOP (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH₂), a highly selective μ-opioid receptor antagonist. By binding to μ-opioid receptors with strong affinity, CTOP effectively blocks the analgesic and behavioral effects of endogenous opioids and exogenous agonists like morphine. Its cyclic disulfide bridge enhances stability and receptor selectivity, making it an essential research tool for dissecting opioid receptor pharmacology. CTOP TFA is widely applied in studies of pain modulation, opioid addiction, and μ-receptor mediated signaling mechanisms in the nervous system.