For research use only. Not for therapeutic Use.
CT52923 (Cat No.: I042304) is a potent and selective antagonist of the neurokinin-1 (NK1) receptor, which binds substance P, a neuropeptide involved in pain transmission, inflammation, and emesis. By blocking NK1 receptor activity, CT52923 is used in research focused on pain modulation, mood disorders, and chemotherapy-induced nausea and vomiting (CINV). It exhibits high affinity and central nervous system penetration, making it valuable in preclinical studies of neurogenic inflammation and stress-related disorders. CT52923 supports the development of NK1-targeted therapeutic strategies in neuroscience and pharmacology.
| CAS Number | 205256-55-9 |
| Synonyms | N-(1,3-benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide |
| Molecular Formula | C23H25N5O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33) |
| InChIKey | ORRFUYVNMZSYIC-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)C(=S)NCC4=CC5=C(C=C4)OCO5)OC |
| Reference | [1]. J C Yu, et al. Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury. J Pharmacol Exp Ther. 2001 Sep;298(3):1172-8. |
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