CP21R7

• CAT Number: I001003
• CAS Number: 125314-13-8
• Molecular Formula: C₁₉H₁₅N₃O₂
• Molecular Weight: 317.35
• Purity: ≥95%
• Target: GSK-3
• Solubility: DMSO: ≥ 34 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C19H15N3O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,20H2,1H3,(H,21,23,24)
• InChIKey: RGTAEYDIDMGJLX-UHFFFAOYSA-N
• SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CC(=CC=C4)N

CP21R7 is a potent and selective GSK-3β inhibitor.CP21R7 can inhibitor enhances the induction of KDR+precursors prior to vascular commitment.Cp21R7 compound induced the highest luciferase activity at a concentration of 3 μ M.[2] Immunofluorescence staining revealed that CP21 significantly increased total levels of intracellular -catenin. Activation of WNT signaling via GSK3 inhibition with CP21 induced commitment of hPSCs towards mesoderm. [3]

Reference

[1]. Sahara M et al. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitorsfrom human pluripotent stem cells, 2015 Jan, 25(1):148

[2]. K. christensen et al. Method for differentiation of pluripotent stem cells into vascular bed cells. Application number, CN 201280028159, Mar 5, 2014.

[3]. Christoph Patsch et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol, 2015 Aug, 17(8): 994-1003.