CP-466722

• CAT Number: I000354
• CAS Number: 1080622-86-1
• Molecular Formula: C₁₇H₁₅N₇O₂
• Molecular Weight: 349.35
• Purity: ≥95%
• Synonyms: 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine
• Target: ATM/ATR
• Solubility: DMSO: 0.28 mg/mL, H2O: <1 mg/mL
• Storage: 2-8°C
• InChI: InChI=1S/C17H15N7O2/c1-25-13-7-10-12(8-14(13)26-2)20-9-21-16(10)24-17(18)22-15(23-24)11-5-3-4-6-19-11/h3-9H,1-2H3,(H2,18,22,23)
• InChIKey: ILBRKJBKDGCSCB-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)N3C(=NC(=N3)C4=CC=CC=N4)N)OC

CP-466722（Cat No.:I000354） is a potent and reversible inhibitor of ATM (ataxia telangiectasia mutated), a protein kinase involved in DNA damage response and repair. Notably, it does not affect ATR (ataxia telangiectasia and Rad3-related) and does not inhibit other members of the PI3K (phosphoinositide 3-kinase) or PIKK (PI3K-related kinase) family. By specifically targeting ATM, CP-466722 holds promise as a valuable tool in studying the cellular functions of ATM and its potential therapeutic applications in diseases related to DNA damage response and genomic instability.

Reference

[1]. Rainey MD et al (2008) Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68(18):7466-74.
[2]. Kuroda S, Urata Y, Fujiwara T.Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization.Acta Med Okayama. 2012;66(2):83-92.