CP-339818

• CAT Number: I006210
• CAS Number: 185855-91-8
• Molecular Formula: C21H25ClN2
• Molecular Weight: 340.895
• Purity: ≥95%
• Synonyms: CP-339818; CP 339818; CP339818; CP-339818 HCl; CP339818HCl.;N-pentyl-1-(phenylmethyl)quinolin-4-imine
• Target: KV1.3 channel antagonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: 1-benzyl-N-pentylquinolin-4-imine;hydrochloride
• InChI: InChI=1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H
• InChIKey: JIRISCAPZWLWCG-UHFFFAOYSA-N
• SMILES: CCCCCN=C1C=CN(C2=CC=CC=C12)CC3=CC=CC=C3.Cl

CP-339818 blocks both Kv1.3 and Kv1.4. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. Kv1.3 is expressed in the brain and in effector memory Tem (T) cells, and it is a member of the Shaker family of voltage-gated potassium channels.

Reference

1: Sforna L, D/’Adamo MC, Servettini I, Guglielmi L, Pessia M, Franciolini F, Catacuzzeno L. Expression and function of a CP339,818-sensitive K⁺ current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia. J Neurophysiol. 2015 Apr 1;113(7):2653-65. doi: 10.1152/jn.00379.2014. PubMed PMID: 25652918; PubMed Central PMCID: PMC4416569.