Corosolic acid

• CAT Number: I003596
• CAS Number: 4547-24-4
• Molecular Formula: C30H48O4
• Molecular Weight: 472.7
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 26.8 μg/ml in vitro

Corosolic acid(CAT: I003596) is a naturally occurring triterpenoid compound found in various plants, including the leaves of the banaba tree (Lagerstroemia speciosa). It has gained attention for its potential medicinal properties, particularly in the management of diabetes and obesity. Corosolic acid has been shown to exhibit antidiabetic effects by enhancing glucose uptake in cells, promoting insulin sensitivity, and inhibiting enzymes involved in carbohydrate metabolism. Additionally, it has demonstrated anti-inflammatory, antioxidant, and anticancer activities in preclinical studies. Corosolic acid holds promise as a natural therapeutic agent, although further research is needed to fully understand its mechanisms of action and therapeutic potential.

Reference

1:Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis. Jia Y, Yuan H, Shan S, Xu G, Yu J, Zhao C, Mou X.Oncol Lett. 2016 Nov;12(5):4187-4194. Epub 2016 Sep 26. PMID: 27895790 Free PMC Article2:Blocking inhibition to YAP by ActinomycinD enhances anti-tumor efficacy of Corosolic acid in treating liver cancer. Xu Y, Zhao Y, Xu Y, Guan Y, Zhang X, Chen Y, Wu Q, Zhu G, Chen Y, Sun F, Wang J, Yu Y.Cell Signal. 2017 Jan;29:209-217. doi: 10.1016/j.cellsig.2016.11.001. Epub 2016 Nov 9. PMID: 27836738 3:Corosolic acid protects hepatocytes against ethanol-induced damage by modulating mitogen-activated protein kinases and activating autophagy. Guo X, Cui R, Zhao J, Mo R, Peng L, Yan M.Eur J Pharmacol. 2016 Nov 15;791:578-588. doi: 10.1016/j.ejphar.2016.09.031. Epub 2016 Sep 20. PMID: 27663281 4:Corosolic acid suppresses the expression of inflammatory marker genes in CCL4-induced-hepatotoxic rats. Balakrishnan A, Al-Assaf AH.Pak J Pharm Sci. 2016 Jul;29(4):1133-8. PMID: 27393448 5:Microbial transformation of the anti-diabetic agent corosolic acid by Cunninghamella echinulata. Feng X, Lu YH, Liu Z, Li DP, Zou YX, Fang YQ, Chu ZY.J Asian Nat Prod Res. 2016 May 30:1-6. doi: 10.1080/10286020.2016.1187140. [Epub ahead of print] PMID: 27240189 6:Corosolic acid inhibits the proliferation of glomerular mesangial cells and protects against diabetic renal damage. Li XQ, Tian W, Liu XX, Zhang K, Huo JC, Liu WJ, Li P, Xiao X, Zhao MG, Cao W.Sci Rep. 2016 May 27;6:26854. doi: 10.1038/srep26854. PMID: 27229751 Free PMC Article7:Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice. Yang J, Leng J, Li JJ, Tang JF, Li Y, Liu BL, Wen XD.Phytomedicine. 2016 Feb 15;23(2):181-90. doi: 10.1016/j.phymed.2015.12.018. Epub 2016 Jan 21. PMID: 26926180 8:Inhibition of Mitochondrial Fission and NOX2 Expression Prevent NLRP3 Inflammasome Activation in the Endothelium: The Role of Corosolic Acid Action in the Amelioration of Endothelial Dysfunction. Li Y, Zhou ZH, Chen MH, Yang J, Leng J, Cao GS, Xin GZ, Liu LF, Kou JP, Liu BL, Li P, Wen XD.Antioxid Redox Signal. 2016 Jun 1;24(16):893-908. doi: 10.1089/ars.2015.6479. Epub 2016 Mar 22. PMID: 26869350 9:Corosolic acid analogue, a natural triterpenoid saponin, induces apoptosis on human hepatocarcinoma cells through mitochondrial pathway in vitro. Qu L, Zhang H, Yang Y, Yang G, Xin H, Ling C.Pharm Biol. 2016 Aug;54(8):1445-57. doi: 10.3109/13880209.2015.1104699. Epub 2016 Jan 25. PMID: 26810384 10:Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages. Kim SJ, Cha JY, Kang HS, Lee JH, Lee JY, Park JH, Bae JH, Song DK, Im SS.BMB Rep. 2016 May;49(5):276-81. PMID: 26615974 Free PMC Article