Conoidin A

• CAT Number: R060757
• CAS Number: 18080-67-6
• Molecular Formula: C10H8Br2N2O2
• Molecular Weight: 347.99
• Purity: ≥95%
• Synonyms: 2,3-Bis(bromomethyl)quinoxaline 1,4-Dioxide
• Target: peroxiredoxins
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 2,3-bis(bromomethyl)-4-oxidoquinoxalin-1-ium 1-oxide
• InChI: InChI=1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2
• InChIKey: DQKNFTLRMZOAMG-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)N(C(=C([N+]2=O)CBr)CBr)[O-]

ConoidinA（Cat No.:R060757） is a cell-permeable inhibitor with nematicidal properties against Toxoplasma gondii peroxidase II (TgPrxII). It covalently binds to the catalytic site Cys47 of TgPrxII, irreversibly inhibiting its peroxide activity with an IC50 of 23 µM. ConoidinA also inhibits the oxidation of mammalian PrxI and PrxII (but not PrxIII). This compound exhibits antioxidant and neuroprotective effects and holds potential for research in ischemic heart disease. Its selective inhibition of TgPrxII makes it a valuable tool for studying T. gondii and other related pathogens.