Complement factor D-IN-2

• CAT Number: I044645
• CAS Number: 1903742-34-6
• Molecular Formula: C27H24BrN7O3
• Molecular Weight: 574.43
• Purity: ≥95%
• Synonyms: (1R,3S,5R)-2-[2-[3-acetyl-5-(2-methylpyrimidin-5-yl)indazol-1-yl]acetyl]-N-(6-bromopyridin-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide
• InChI: InChI=1S/C27H24BrN7O3/c1-14(36)26-19-8-16(18-11-29-15(2)30-12-18)6-7-20(19)34(33-26)13-25(37)35-21-9-17(21)10-22(35)27(38)32-24-5-3-4-23(28)31-24/h3-8,11-12,17,21-22H,9-10,13H2,1-2H3,(H,31,32,38)/t17-,21-,22+/m1/s1
• InChIKey: JLRVDNFYMDBUJT-YHYVQYDKSA-N
• SMILES: CC1=NC=C(C=N1)C2=CC3=C(C=C2)N(N=C3C(=O)C)CC(=O)N4[C@@H]5C[C@@H]5C[C@H]4C(=O)NC6=NC(=CC=C6)Br

Complement factor D-IN-2（Cat No.:I044645）is a potent, selective small-molecule inhibitor of complement factor D, a serine protease essential for activating the alternative complement pathway. By blocking factor D, it prevents the cleavage of factor B and formation of the C3 convertase, thereby reducing downstream complement activation and inflammation. With a molecular formula of C₂₇H₂₄BrN₇O₃ and molecular weight of 574.43 g/mol, it is supplied as a high-purity solid and is soluble in DMSO. Complement factor D-IN-2 is used in immunology research, particularly for studying complement-mediated diseases and therapeutic intervention strategies.