Colchicine

• CAT Number: I004443
• CAS Number: 64-86-8
• Molecular Formula: C₂₂H₂₅NO₆
• Molecular Weight: 399.4
• Purity: ≥95%
• Target: Microtubule/Tubulin
• Solubility: DMSO: ≥ 48 mg/mL
• Storage: Store at -20°C
• IC50: 3.2 μM
• IUPAC Name: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• InChI: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
• InChIKey: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Colchicine (Cat.No:I004443) is a natural plant-derived compound commonly used in the treatment of gout and other inflammatory conditions. It works by inhibiting the microtubule polymerization process, disrupting cell division and inflammatory processes. Colchicine has anti-inflammatory and analgesic properties and is often prescribed to alleviate acute gout attacks. It is also being studied for its potential in treating other inflammatory disorders and certain types of cancer.

Reference

1:Morphological, physiological, cytological and phytochemical studies in diploid and colchicine-induced tetraploid plants of Fagopyrum tataricum (L.) Gaertn. Wang LJ, Sheng MY, Wen PC, Du JY.Bot Stud. 2017 Dec;58(1):2. doi: 10.1186/s40529-016-0157-3. Epub 2017 Jan 2. PMID: 28510185 Free Article2:Colchicine may assist in reducing granulation tissue in junctional epidermolysis bullosa. Kim M, Jain S, Harris AG, Murrell DF.Int J Womens Dermatol. 2016 May 19;2(2):56-59. doi: 10.1016/j.ijwd.2016.04.001. eCollection 2016 Jun. PMID: 28492007 Free PMC Article3:Colchicine attenuates renal fibrosis in a murine unilateral ureteral obstruction model. Itano S, Satoh M, Kadoya H, Sogawa Y, Uchida A, Sasaki T, Kashihara N.Mol Med Rep. 2017 Jun;15(6):4169-4175. doi: 10.3892/mmr.2017.6539. Epub 2017 May 2. PMID: 28487937 4:Microbial Catalyzed Regio-Selective Demethylation of Colchicine by Streptomyces griseus ATCC 13273. Zhang C, Sun X, Xu SH, Yu BY, Zhang J.Appl Biochem Biotechnol. 2017 Apr 28. doi: 10.1007/s12010-017-2480-x. [Epub ahead of print] PMID: 28455804 5:Anagen Effluvium Following Acute Colchicine Poisoning. Combalia A, Baliu-Piqué C, Fortea A, Ferrando J.Int J Trichology. 2016 Oct-Dec;8(4):171-172. doi: 10.4103/0974-7753.203171. PMID: 28442873 Free PMC Article6:Biotherapeutic potential and mechanisms of action of colchicine. Dubey KK, Kumar P, Labrou NE, Shukla P.Crit Rev Biotechnol. 2017 Apr 23:1-10. doi: 10.1080/07388551.2017.1303804. [Epub ahead of print] PMID: 28436240 7:Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction. Fujisue K, Sugamura K, Kurokawa H, Matsubara J, Ishii M, Izumiya Y, Kaikita K, Sugiyama S.Circ J. 2017 Apr 18. doi: 10.1253/circj.CJ-16-0949. [Epub ahead of print] PMID: 28420825 Free Article8:Colchicine resistance and intolerance in familial mediterranean fever: Definition, causes, and alternative treatments. Ozen S, Kone-Paut I, Gül A.Semin Arthritis Rheum. 2017 Mar 20. pii: S0049-0172(16)30330-4. doi: 10.1016/j.semarthrit.2017.03.006. [Epub ahead of print] Review. PMID: 28413100 Free Article9:Upstream biomanufacturing of pharmaceutical colchicine. Sivakumar G.Crit Rev Biotechnol. 2017 Apr 12:1-10. doi: 10.1080/07388551.2017.1312269. [Epub ahead of print] PMID: 28399663 10:Interest of colchicine in the treatment of acute myocardial infarct responsible for heart failure in a mouse model. Akodad M, Fauconnier J, Sicard P, Huet F, Blandel F, Bourret A, de Santa Barbara P, Aguilhon S, LeGall M, Hugon G, Lacampagne A, Roubille F.Int J Cardiol. 2017 Apr 1. pii: S0167-5273(16)34092-X. doi: 10.1016/j.ijcard.2017.03.126. [Epub ahead of print] PMID: 28395979