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Cobimetinib (R-enantiomer)

Cobimetinib (R-enantiomer)

  • CAT Number: I005551
  • CAS Number: 934660-94-3
  • Molecular Formula: C21H21F3IN3O2
  • Molecular Weight: 531.31
  • Purity: ≥95%
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GDC-0973(XL-518) is a selective inhibitor of MEK. GDC-0973 is also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors. Inappropriate activation of the MEK/ERK pathway promotes cell growth in the absence of exogenous growth factors.

Catalog Number I005551
CAS Number 934660-94-3
Synonyms

R-Cobimetinib

Molecular Formula

C21H21F3IN3O2

Purity 95%
Target MEK1/2
Solubility 10 mM in DMSO
Storage Store at -20°C
Reference

1 . Hoeflich KP, Merchant M, Orr C, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9. 

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