CMX-2043

• CAT Number: I006182
• CAS Number: 910627-26-8
• Molecular Formula: C16H26N2O6S2
• Molecular Weight: 406.512
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: (4S)-5-[[(1S)-1-carboxyethyl]amino]-4-[5-[(3R)-dithiolan-3-yl]pentanoylamino]-5-oxopentanoic acid
• InChI: InChI=1S/C16H26N2O6S2/c1-10(16(23)24)17-15(22)12(6-7-14(20)21)18-13(19)5-3-2-4-11-8-9-25-26-11/h10-12H,2-9H2,1H3,(H,17,22)(H,18,19)(H,20,21)(H,23,24)/t10-,11+,12-/m0/s1
• InChIKey: MQXRTCVZPIHBLD-TUAOUCFPSA-N
• SMILES: CC(C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CCCCC1CCSS1

CMX-2043 is a drug potentially to activate cell survival pathways and block oxidative damage.

Reference

1:CMX-2043 Mechanisms of Action In Vitro. Lader AS, Baguisi A, Casale R, Kates SA, Beeuwkes R 3rd.J Cardiovasc Pharmacol. 2016 Sep;68(3):241-7. doi: 10.1097/FJC.0000000000000408. PMID: 27195653 2:CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia-Reperfusion Injury. Baguisi A, Casale RA, Kates SA, Lader AS, Stewart K, Beeuwkes R 3rd.J Cardiovasc Pharmacol Ther. 2016 Nov;21(6):563-569. Epub 2016 Apr 24. PMID: 27113210 3:Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury. Kates SA, Lader AS, Casale R, Beeuwkes R 3rd.Basic Clin Pharmacol Toxicol. 2014 Nov;115(5):456-64. doi: 10.1111/bcpt.12254. Epub 2014 May 16. PMID: 24751172 Free PMC Article