For research use only. Not for therapeutic Use.
CMF019（Cat No.:I017997）is a selective small-molecule agonist of the apelin receptor (APJ), a G protein–coupled receptor implicated in cardiovascular regulation, angiogenesis, and fluid homeostasis. By activating APJ, CMF019 enhances vasodilation, improves cardiac output, and influences vascular remodeling, making it a useful tool for studying cardiovascular physiology and disease. It is employed in preclinical research to explore novel therapeutic strategies for heart failure, pulmonary hypertension, and related vascular disorders. CMF019 provides mechanistic insights into apelinergic signaling.
| CAS Number | 1586787-08-7 |
| Synonyms | (3S)-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazole-5-carbonyl]amino]hexanoic acid |
| Molecular Formula | C25H33N3O3S |
| Purity | ≥95% |
| IUPAC Name | (3S)-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazole-5-carbonyl]amino]hexanoic acid |
| InChI | InChI=1S/C25H33N3O3S/c1-5-19(6-2)28-22-10-9-17(25(31)26-18(12-16(3)4)14-24(29)30)13-21(22)27-23(28)15-20-8-7-11-32-20/h7-11,13,16,18-19H,5-6,12,14-15H2,1-4H3,(H,26,31)(H,29,30)/t18-/m0/s1 |
| InChIKey | VCQKKZXFASLXAH-SFHVURJKSA-N |
| SMILES | CCC(CC)N1C2=C(C=C(C=C2)C(=O)N[C@@H](CC(C)C)CC(=O)O)N=C1CC3=CC=CS3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
