CMC2.24

• CAT Number: I045536
• CAS Number: 1255639-43-0
• Molecular Formula: C26H21NO5
• Molecular Weight: 427.45
• Purity: ≥95%
• Synonyms: (E)-5-(4-hydroxyphenyl)-2-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-3-oxo-N-phenylpent-4-enamide
• InChI: InChI=1S/C26H21NO5/c28-21-12-6-18(7-13-21)10-16-23(30)25(26(32)27-20-4-2-1-3-5-20)24(31)17-11-19-8-14-22(29)15-9-19/h1-17,25,28-29H,(H,27,32)/b16-10+,17-11+
• InChIKey: ZPZMHBPRQOJARQ-OTYYAQKOSA-N
• SMILES: C1=CC=C(C=C1)NC(=O)C(C(=O)C=CC2=CC=C(C=C2)O)C(=O)C=CC3=CC=C(C=C3)O

CMC2.24 (Cat No.: I045536) is a chemically modified curcumin derivative designed to improve the bioavailability and stability of natural curcumin. It retains curcumin’s anti-inflammatory and antioxidant properties while exhibiting enhanced pharmacokinetics. CMC2.24 has been studied for its ability to inhibit matrix metalloproteinases (MMPs) and modulate inflammatory signaling, making it a promising candidate for treating periodontal disease, chronic inflammation, and cancer-related processes. Its optimized structure allows for more effective suppression of tissue-destructive enzymes, positioning it as a valuable therapeutic lead in inflammation and oncology research.

Reference

[1]. Mallangada NA, et al. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. Mol Carcinog. 2018;57(9):1130-1143.
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[2]. Zhou Y, et al. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med (Berl). 2020;98(10):1479-1491.
[Content Brief]

[3]. Zhang Y, et al. Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins. Curr Med Chem. 2012;19(25):4348-4358.
[Content Brief]