Cloprostenol sodium

• CAT Number: A001233
• CAS Number: 55028-72-3
• Molecular Formula: C22H28ClNaO6
• Molecular Weight: 446.9
• Purity: ≥95%
• Target: Prostanoid Receptors
• Solubility: Soluble to 20 mM in sterile water
• Storage: Desiccate at -20°C
• Related CAS: 40665-92-7(free acid)
• IUPAC Name: sodium;(Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
• InChI: InChI=1S/C22H29ClO6.Na/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);/q;+1/p-1/b3-1-,11-10+;/t16-,18-,19-,20+,21-;/m1./s1
• InChIKey: IFEJLMHZNQJGQU-KXXGZHCCSA-M
• SMILES: O[C@@H]1[C@H](C/C=CCCCC([O-])=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(Cl)=C2)[C@H](O)C1.[Na+]

Cloprostenol sodium salt (Cat. No: A001233) is a synthetic and effective prostaglandin analogue, mainly as an agonist of PGF2α receptor. Its pharmacological action is to dissolve the corpus luteum, reduce the concentration of progesterone in the blood.

Reference

1: Martins JP, Policelli RK, Pursley JR. Luteolytic effects of cloprostenol sodium in lactating dairy cows treated with G6G/Ovsynch. J Dairy Sci. 2011 Jun;94(6):2806-14. doi: 10.3168/jds.2010-3650. PubMed PMID: 21605750.
2: Hu Y, Wright MD, Dyer RM, Nephew KP, Bolze RP, Day ML. Effects of cloprostenol sodium and clenbuterol HCl on reproductive performance in postpartum anestrous cows. Theriogenology. 1990 Jul;34(1):127-32. PubMed PMID: 16726822.
3: Turner TB, Peterson GA, Davis ME, Wilson GR, Irvin KM, Forry JT. Synchronization of estrus in beef cows and heifers with fenprostalene, cloprostenol sodium, and prostaglandin F2 alpha. Theriogenology. 1987 Jul;28(1):15-24. PubMed PMID: 16726288.