Clopidogrel

  • CAT Number: I000517
  • CAS Number: 113665-84-2
  • Molecular Formula: C16H16ClNO2S
  • Molecular Weight: 321.819
  • Purity: ≥95%
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Clopidogrel (CAT: I000517) is an antiplatelet medication used to reduce the risk of blood clots in patients with cardiovascular diseases. It belongs to the class of drugs known as thienopyridine derivatives. Clopidogrel works by irreversibly inhibiting the P2Y12 receptor on platelets, which prevents platelet aggregation and reduces the formation of blood clots. It is commonly prescribed to patients with a history of myocardial infarction, stroke, or peripheral artery disease. Clopidogrel is often used in combination with aspirin for enhanced antiplatelet effects and is an essential component of preventive therapy in cardiovascular medicine.

Catalog Number I000517
CAS Number 113665-84-2
Molecular Formula

C16H16ClNO2S

Purity 95%
Target P2Y12 receptor
Solubility 10 mM in DMSO
Storage Store at -20C
IUPAC Name methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
InChI InChI=1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1
InChIKey GKTWGGQPFAXNFI-HNNXBMFYSA-N
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Reference

1: Ford NF. The Metabolism of Clopidogrel: CYP2C19 Is a Minor Pathway. J Clin
Pharmacol. 2016 Dec;56(12):1474-1483. doi: 10.1002/jcph.769. Epub 2016 Jun 22.
Review. PubMed PMID: 27196064. <br />
2: Jiang XL, Samant S, Lesko LJ, Schmidt S. Clinical pharmacokinetics and
pharmacodynamics of clopidogrel. Clin Pharmacokinet. 2015 Feb;54(2):147-66. doi:
10.1007/s40262-014-0230-6. Review. PubMed PMID: 25559342. <br />
3: Cialdella P, Gustapane M, Camaioni C, Biasucci LM. What/’s new about
clopidogrel. Minerva Cardioangiol. 2013 Dec;61(6):683-9. Review. PubMed PMID:
24253460. <br />
4: Swiger KJ, Yousuf O, Bliden KP, Tantry US, Gurbel PA. Cigarette smoking and
clopidogrel interaction. Curr Cardiol Rep. 2013 May;15(5):361. doi:
10.1007/s11886-013-0361-7. Review. PubMed PMID: 23591705. <br />
5: Feely MA, Mabry TM, Lohse CM, Sems SA, Mauck KF. Safety of clopidogrel in hip
fracture surgery. Mayo Clin Proc. 2013 Feb;88(2):149-56. doi:
10.1016/j.mayocp.2012.11.007. PubMed PMID: 23374618; PubMed Central PMCID:
PMC3837691.

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