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Clemizole HCl

Clemizole HCl

  • CAT Number: I004937
  • CAS Number: 1163-36-6 (HCl)
  • Molecular Formula: C19H21Cl2N3
  • Molecular Weight: 362.298
  • Purity: ≥95%
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Clemizole, also known as AL 20, P 48, or Reactrol, is a potent inhibitor of transient receptor potential channel TRPC5. Clemizole efficiently blocks TRPC5 currents and Ca(2+) entry in the low micromolar range (IC50 = 1.0-1.3 µM). Clemizole blocks TRPC5 cu

Catalog Number I004937
CAS Number 1163-36-6 (HCl)
Molecular Formula

C19H21Cl2N3

Purity 95%
Target TRPC5 inhibitor
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term or -20 °C for long term
IUPAC Name 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;hydrochloride
InChI InChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
InChIKey DNFMJYXRIMLMBZ-UHFFFAOYSA-N
SMILES C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl.Cl
Reference

</br>1: Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. doi: 10.1124/mol.114.093229. Epub 2014 Aug 19. PubMed PMID: 25140002.</br

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