Clamikalant sodium

For research use only. Not for therapeutic Use.

  • CAT Number: I045071
  • CAS Number: 261717-22-0
  • Molecular Formula: C19H21ClN3NaO5S2
  • Molecular Weight: 493.96
  • Purity: ≥95%
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Clamikalant sodium(Cat No.:I045071)is the sodium salt form of clamikalant, a selective potassium channel blocker targeting the Kv1.5 channel subtype. Kv1.5 channels are predominantly expressed in atrial tissue and are involved in regulating cardiac action potential duration. By inhibiting these channels, clamikalant sodium aims to prolong atrial repolarization without affecting ventricular function, offering a potential antiarrhythmic strategy for the treatment of atrial fibrillation. Its atrial-selective mechanism reduces the risk of proarrhythmic effects commonly associated with non-selective ion channel blockers. Clamikalant sodium is primarily investigated in preclinical and early clinical cardiac research.


CAS Number 261717-22-0
Synonyms

sodium;(5-chloro-2-methoxybenzoyl)-[2-[4-methoxy-3-(methylcarbamothioylsulfamoyl)phenyl]ethyl]azanide

Molecular Formula C19H21ClN3NaO5S2
Purity ≥95%
IUPAC Name sodium;(5-chloro-2-methoxybenzoyl)-[2-[4-methoxy-3-(methylcarbamothioylsulfamoyl)phenyl]ethyl]azanide
InChI InChI=1S/C19H22ClN3O5S2.Na/c1-21-19(29)23-30(25,26)17-10-12(4-6-16(17)28-3)8-9-22-18(24)14-11-13(20)5-7-15(14)27-2;/h4-7,10-11H,8-9H2,1-3H3,(H3,21,22,23,24,29);/q;+1/p-1
InChIKey SUEVHDKFEXAKAF-UHFFFAOYSA-M
SMILES CNC(=S)NS(=O)(=O)C1=C(C=CC(=C1)CC[N-]C(=O)C2=C(C=CC(=C2)Cl)OC)OC.[Na+]
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