CL075

• CAT Number: I011586
• CAS Number: 256922-53-9
• Molecular Formula: C13H13N3S
• Molecular Weight: 243.33
• Purity: ≥95%
• Synonyms: 2-propyl-[1,3]thiazolo[4,5-c]quinolin-4-amine
• InChI: InChI=1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)
• InChIKey: NFYMGJSUKCDVJR-UHFFFAOYSA-N
• SMILES: CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N

CL075 (Cat No.: I011586) is a synthetic imidazoquinoline derivative that acts as a potent Toll-like receptor 7/8 (TLR7/8) agonist, stimulating innate immune responses. By activating endosomal TLR7/8, CL075 induces the production of type I interferons and pro-inflammatory cytokines, mimicking viral RNA recognition. It is widely used in immunology research to investigate innate immune signaling, antiviral defense, vaccine adjuvant design, and cancer immunotherapy. CL075 provides a valuable experimental tool for exploring pattern recognition receptor pathways and developing strategies that harness the immune system for therapeutic purposes.

Reference

[1]. Lai CY, et, al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014 Sep 29;32(43):5593-9.
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[2]. Spranger S, et, al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010 Jul 1;185(1):738-47.
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[3]. Maalej KM, et, al. TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils. J Leukoc Biol. 2015 Jun;97(6):1081-7.
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