Ciprofloxacin hydrochloride

• CAT Number: R064565
• CAS Number: 93107-08-5
• Molecular Formula: C17H18FN3O3 • HCl
• Molecular Weight: 367.8
• Purity: ≥95%
• Target: Antibiotic
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
• InChIKey: DIOIOSKKIYDRIQ-UHFFFAOYSA-N
• SMILES: FC1=CC2=C(C=C1N3CCNCC3)N(C4CC4)C=C(C(O)=O)C2=O.Cl

Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline, an fluoroquinolone antibiotic that is widely used as an antimicrobial and immunomodulatory agent. It is capable of inducing respiratory, urinary tract, gastrointestinal, and abdominal infections. It functions by inhibiting DNA gyrase (a type II topoisomerase) and topoisomerase IV, the enzymes responsible for negative supercoiling of chromosomes and DNA strand separation, thus blocking initiation of bacterial replication. Most recently ciprofloxacin has been used in the management of postexposure inhalational anthrax and radiation combined injury resulting from nuclear disasters.

Reference

1:Poly (vinyl alcohol)/poly (acrylamide-co-diallyldimethyl ammonium chloride) semi-IPN hydrogels for ciprofloxacin hydrochloride drug delivery. Sana SS, Boya VKN.IET Nanobiotechnol. 2017 Feb;11(1):52-56. doi: 10.1049/iet-nbt.2016.0079. PMID: 28476961 2:Nano-zinc oxide incorporated graphene oxide/nanocellulose composite for the adsorption and photo catalytic degradation of ciprofloxacin hydrochloride from aqueous solutions. Anirudhan TS, Deepa JR.J Colloid Interface Sci. 2017 Mar 15;490:343-356. doi: 10.1016/j.jcis.2016.11.042. Epub 2016 Nov 17. PMID: 27914333 3:Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach. Karimi K, Pallagi E, Szabó-Révész P, Csóka I, Ambrus R.Drug Des Devel Ther. 2016 Oct 12;10:3331-3343. eCollection 2016. PMID: 27784991 Free PMC Article4:The nanocrystalline coordination polymer of AMT-Ag for an effective detection of ciprofloxacin hydrochloride in pharmaceutical formulation and biological fluid. Tiwari M, Kumar A, Shankar U, Prakash R.Biosens Bioelectron. 2016 Nov 15;85:529-35. doi: 10.1016/j.bios.2016.05.049. Epub 2016 May 15. PMID: 27236138 5:[Photodegradation of Ciprofloxacin Hydrochloride in the Aqueous Solution Under UV]. Duan LC, Wang FH, Zhao B, Chen YJ.Huan Jing Ke Xue. 2016 Jan 15;37(1):198-207. Chinese. PMID: 27078959 6:Investigation of Biowaivers for Immediate Release Formulations Containing BCS III Drugs, Acyclovir, Atenolol, and Ciprofloxacin Hydrochloride, Using Dissolution Testing. Reddy NH, Patnala S, Kanfer I.AAPS PharmSciTech. 2017 Feb;18(2):424-431. doi: 10.1208/s12249-016-0520-4. Epub 2016 Apr 1. PMID: 27038483 7:Antibacterial ciprofloxacin hydrochloride incorporated PVA/regenerated silk fibroin nanofibers composite for wound dressing applications. El-Shanshory AA, Chen W, El-Hamshary HA, Al-Deyab SS, Mo X.J Control Release. 2015 Sep 10;213:e8-9. doi: 10.1016/j.jconrel.2015.05.010. Epub 2015 Aug 19. No abstract available. PMID: 27005232 8:Development and characterization of in-situ gel for ophthalmic formulation containing ciprofloxacin hydrochloride. Makwana SB, Patel VA, Parmar SJ.Results Pharma Sci. 2015 Jul 8;6:1-6. doi: 10.1016/j.rinphs.2015.06.001. eCollection 2016. PMID: 26949596 Free PMC Article9:Spectrophotometric and chemometric methods for determination of imipenem, ciprofloxacin hydrochloride, dexamethasone sodium phosphate, paracetamol and cilastatin sodium in human urine. El-Kosasy AM, Abdel-Aziz O, Magdy N, El Zahar NM.Spectrochim Acta A Mol Biomol Spectrosc. 2016 Mar 15;157:26-33. doi: 10.1016/j.saa.2015.12.011. Epub 2015 Dec 12. PMID: 26709018 10:[Radiolytic Decomposition of Ciprofloxacin Hydrochloride in Aqueous Solution Using γ Irradiation]. Zhu SN, Guo ZB, Zhao YF, Ge X, Wei Y, Chen S, Wang J.Huan Jing Ke Xue. 2015 Apr;36(4):1332-7. Chinese. PMID: 26164908