For research use only. Not for therapeutic Use.
CINPA1(CAT: I011252) is a potent and selective constitutive androstane receptor (CAR) inhibitor that does not activate the pregnane X receptor (PXR), making it a valuable molecular probe for studying xenobiotic receptor signaling. It reduces CAR-mediated transcription with an IC50 of ~70 nM and blocks CAR transactivation in HepG2 cells without PXR activation. In primary human hepatocytes, CINPA1 suppresses CAR-dependent gene expression without altering CAR protein levels or localization. Mechanistically, CINPA1 increases corepressor binding, reduces coactivator recruitment, and disrupts CAR-promoter interactions, confirming its role as a CAR ligand. It is widely applied in drug metabolism, toxicology, and liver disease research.
| CAS Number | 102636-74-8 |
| Synonyms | ethyl N-[11-[2-(diethylamino)acetyl]-5,6-dihydrobenzo[b][1]benzazepin-2-yl]carbamate |
| Molecular Formula | C23H29N3O3 |
| Purity | ≥95% |
| IUPAC Name | ethyl N-[11-[2-(diethylamino)acetyl]-5,6-dihydrobenzo[b][1]benzazepin-2-yl]carbamate |
| InChI | InChI=1S/C23H29N3O3/c1-4-25(5-2)16-22(27)26-20-10-8-7-9-17(20)11-12-18-13-14-19(15-21(18)26)24-23(28)29-6-3/h7-10,13-15H,4-6,11-12,16H2,1-3H3,(H,24,28) |
| InChIKey | AYQBYSPEGRYKFA-UHFFFAOYSA-N |
| SMILES | CCN(CC)CC(=O)N1C2=CC=CC=C2CCC3=C1C=C(C=C3)NC(=O)OCC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
