Almitrine Dimesylate

• CAT Number: I002228
• CAS Number: 29608-49-9
• Molecular Formula: C28H37F2N7O6S2
• Molecular Weight: 669.764
• Purity: ≥95%
• Synonyms: Vectarion; Almitrin; Almitrina; Almitrinum; Almitrine.;6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-N,N/’-diprop-2-enyl-1,3,5-triazine-2,4-diamine
• Target: Peripheral Chemoreceptor Agonist
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 0-8 °C
• IUPAC Name: 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine;methanesulfonic acid
• InChI: InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)
• InChIKey: MRDBGMJEPGXQHJ-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)O.CS(=O)(=O)O.C=CCNC1=NC(=NC(=N1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)NCC=C

Almitrine Dimesylate (marketed as Duxil by Servier) is a diphenylmethylpiperazine derivative classified as a respiratory stimulant by the ATC. It enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.

Reference

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