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Cilobradine hydrochloride

Cilobradine hydrochloride

  • CAT Number: I002399
  • CAS Number: 186097-54-1
  • Molecular Formula: C28H38N2O5 • HCl
  • Molecular Weight: 519.1
  • Purity: ≥95%
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<p style=/line-height:25px/>Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.<br>Target: HCN Channel blocker<br>Cilobradine is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of Cilobradine. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine (8 ± 2% inhibition; n = 4).</p>

Catalog Number I002399
CAS Number 186097-54-1
Molecular Formula

C28H38N2O5 • HCl

Purity 95%
Target HCN Channel blocker
Solubility 10 mM in H2O
Storage -20°C
InChIKey MTAKUIYCCYKGJJ-UHFFFAOYSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939.

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