Cilnidipine

• CAT Number: A000275
• CAS Number: 132203-70-4
• Molecular Formula: C27H28N2O7
• Molecular Weight: 492.52
• Purity: ≥95%
• Target: Calcium Channel
• Solubility: >24.6mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
• InChIKey: KJEBULYHNRNJTE-DHZHZOJOSA-N
• SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC

Cilnidipine, also known as FRC-8653, is a calcium channel blocker. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function. It was approved in 1995. Compared with other calcium antagonists, cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium antagonists.

Reference

1: Shetty K, Shetty R, Rao P, Ballal M, Kiran A, Reddy S, Pai U, Samanth J.
Comparison of Plasma Levels of Renin, Vasopressin and Atrial Natriuretic Peptide
in Hypertensive Amlodipine Induced Pedal Oedema, Non-Oedema and Cilnidipine
Treated Patients. J Clin Diagn Res. 2017 Jun;11(6):FC05-FC08. doi:
10.7860/JCDR/2017/25097.9958. Epub 2017 Jun 1. PubMed PMID: 28764190; PubMed
Central PMCID: PMC5535383.

2: Shetty K, Shetty R, Bairy L, Rao P, Kiran A, Shetty M, Deepak, Nayak V. A
Comparative Study on Clinical and Biochemical Parameters in Amlodipine and
Cilnidipine Treated Hypertensive Patients. J Clin Diagn Res. 2017
May;11(5):FC01-FC05. doi: 10.7860/JCDR/2017/23825.9763. Epub 2017 May 1. PubMed
PMID: 28658794; PubMed Central PMCID: PMC5483696.

3: Lu CW, Lin TY, Huang SK, Wang SJ. Inhibition of glutamate release by
cilnidipine in rat cerebrocortical nerve terminals (synaptosomes). Neuroreport.
2017 Jun 14;28(9):527-532. doi: 10.1097/WNR.0000000000000795. PubMed PMID:
28498149.

4: Aoki S, Hosomi N, Nezu T, Teshima T, Sugii H, Nagahama S, Kurose Y, Maruyama
H, Matsumoto M. Blood pressure control with cilnidipine treatment in Japanese
post-stroke hypertensive patients: The CA-ATTEND study. Clin Exp Hypertens.
2017;39(3):225-234. doi: 10.1080/10641963.2016.1235183. PubMed PMID: 28448181.

5: Kumar P, Das A, Chandra S, Gari M, Keshri US, Kumari K. Serum Triglyceride
Lowering Effect of Cilnidipine in Patients With Essential Hypertension. Cardiol
Res. 2016 Oct;7(5):173-177. doi: 10.14740/cr497w. Epub 2016 Nov 3. PubMed PMID:
28197288; PubMed Central PMCID: PMC5295564.

6: Das A, Kumar P, Kumari A, Chandra S, Gari M, Singh N, Dey D. Effects of
Cilnidipine on Heart Rate and Uric Acid Metabolism in Patients With Essential
Hypertension. Cardiol Res. 2016 Oct;7(5):167-172. doi: 10.14740/cr494w. Epub 2016
Nov 3. PubMed PMID: 28197287; PubMed Central PMCID: PMC5295563.

7: Yamamoto S, Suzuki Y, Ono H, Kume K, Ohsawa M. N- and L-type calcium channels
blocker cilnidipine ameliorates neuropathic pain. Eur J Pharmacol. 2016 Dec
15;793:66-75. doi: 10.1016/j.ejphar.2016.11.001. Epub 2016 Nov 5. PubMed PMID:
27823932.

8: Shete MM. Cilnidipine: Next Generation Calcium Channel Blocker. J Assoc
Physicians India. 2016 Apr;64(4):95-99. PubMed PMID: 27734656.

9: Zeng H, Wang F, Zhu B, Zhong W, Shan W, Wang J. Study of the structures of
photodegradation impurities and pathways of photodegradation of cilnidipine by
liquid chromatography/Q-Orbitrap mass spectrometry. Rapid Commun Mass Spectrom.
2016 Aug 15;30(15):1771-8. doi: 10.1002/rcm.7657. PubMed PMID: 27426453.

10: Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. L/N-type
Ca(2+) channels blocker cilnidipine ameliorated the repolarization abnormality in
a chronic hemodialysis patient. Heart Vessels. 2017 Jan;32(1):105-108. doi:
10.1007/s00380-016-0865-3. Epub 2016 Jun 20. PubMed PMID: 27325120.